![]() N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug appears in the circulation because of biotransformation in the liver. In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. The chance of side effects may be increased.Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of application, duration of exposure, concentration, and total dosage. Traumatized mucosa, severe-Use with caution. Large sores, broken skin, or severe injury at the area of application or Infection at or near the place of application or May increase risk of having methemoglobinemia. Methemoglobinemia (blood disorder), hereditary or idiopathic (unknown cause)-Use with caution. Glucose-6-phosphate dehydrogenase deficiency (G6PD) or Make sure you tell your doctor if you have any other medical problems, especially: The presence of other medical problems may affect the use of this medicine. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using alcohol or tobacco with certain medicines may also cause interactions to occur. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Ĭertain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. ![]() Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is not recommended. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Drug InteractionsĪlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Recommended doses should not be exceeded, and the patient should be carefully monitored during treatment. However, because of this medicine's toxicity, it should be used with caution, after other medicines have been considered or found ineffective. No information is available on the relationship of age to the effects of lidocaine topical in geriatric patients. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine. GeriatricĪppropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Ztlido® skin patch in the elderly. Safety and efficacy have not been established. ![]() ![]() Do not give lidocaine viscous topical solution for teething pain.Īppropriate studies have not been performed on the relationship of age to the effects of lidocaine jelly or skin patch in the pediatric population. Pediatricīecause of this medicine's toxicity, it should be used with extreme caution in children younger than 3 years of age, only after other medicines have been considered or found ineffective. For non-prescription products, read the label or package ingredients carefully. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |